Iñaki Godoy as Monkey D. Luffy: The main protagonist of the series, Luffy is a young man who dreams of becoming the King of the Pirates. He has the power to stretch his body like rubber.
Emily Rudd as Nami: A thief and navigator, Nami is a skilled navigator who is essential to the Straw Hat Pirates.
Mackenyu as Roronoa Zoro: Luffy's first crewmate, Zoro is a skilled swordsman who is determined to become the greatest swordsman in the world.
Jacob Romero Gibson as Usopp: A sniper and liar, Usopp is a member of the Straw Hat Pirates who is known for his cowardly but brave personality.
Taz Skylar as Sanji: A chef and martial artist, Sanji is a member of the Straw Hat Pirates who is known for his womanizing ways.
Morgan Davies as Koby: A young marine who admires Luffy, Koby is a character who will be introduced in the first season of the series.
Ilia Isorelýs Paulino as Rebecca: A princess from the Dressrosa kingdom, Rebecca is a character who will be introduced in the second season of the series.
Peter Gadiot as Shanks: A legendary pirate who inspired Luffy to become a pirate, Shanks is a character who will be introduced in the first season of the series.